A novel general route to the synthesis of carboxylic acid esters and thiolesters

✍ Scribed by K. Sucheta; G.S.R. Reddy; D. Ravi; N. Rama Rao

• Publisher: Elsevier Science
• Year: 1994
• Tongue: French
• Weight: 135 KB
• Volume: 35
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)73371-5

✦ Synopsis

Carboxylic acids were conveniently esterfied with alcohols and thiols by the use of triphenylphosphine and N-bromo/Iodo succinimide to afford the corresponding esters and thiol esters. Conversion of carboxylic acids to their corresponding esters and thiol esters is a well established fundamental organic reaction'. It's wide use in organic synthesis has instigated many researchers to develop elegant synthetic methods 2-6 _ We, here in this letter, report a mild, general method for the convenient conversion of carboxylic acids to their corresponding esters by using triphenylphosphine and N-bromo/iodo succinimides. Thus, several acids were smoothly esterfied with diverse alcohols, thiols and obtained the esters and thiol esters in high yield ( adhere 1 ).