A novel function for the protein tyrosine phosphatase Shp2 during lung branching morphogenesis
β Scribed by Denise Tefft; Stijn P. De Langhe; Pierre-Marie Del Moral; Frederic Sala; Wei Shi; Saverio Bellusci; David Warburton
- Book ID
- 116975189
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 534 KB
- Volume
- 282
- Category
- Article
- ISSN
- 0012-1606
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Tyrosine phosphatase Src-homology phosphotyrosyl phosphatase 2 (Shp2) was identified as a potential molecular target for therapeutic treatment of diabetes and obesity. However, there is still no systematic research on the enhancers for the Shp2 enzyme. The present study established a novel powerful
## Abstract The protein tyrosine phosphatase SHPβ1 plays an important role in many physiological and pathophysiological processes. This phosphatase is activated through binding of ligands to its SH2βdomains, mainly to the Nβterminal one. Based on a theoretical docking model, backboneβtoβside chain