✦ LIBER ✦

A novel screening model for the molecular drug for diabetes and obesity based on tyrosine phosphatase Shp2

✍ Scribed by Yanyan Bu; Tao Shi; Minghui Meng; Guiping Kong; Yingpu Tian; Quancheng Chen; Xinsheng Yao; Gensheng Feng; Haifeng Cheng; Zhongxian Lu

Book ID: 104005123
Publisher: Elsevier Science
Year: 2011
Tongue: English
Weight: 753 KB
Volume: 21
Category: Article
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2010.11.049

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✦ Synopsis

Tyrosine phosphatase Src-homology phosphotyrosyl phosphatase 2 (Shp2) was identified as a potential molecular target for therapeutic treatment of diabetes and obesity. However, there is still no systematic research on the enhancers for the Shp2 enzyme. The present study established a novel powerful model for the high-throughput screening of Shp2 enhancers and successfully identified a new specific Shp2 enhancer, oleanolic acid, from Chinese herbs.

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