Compounds of type ( I ) and ( ) are key substances for the synthesis of highly active corticoids'll such as dexamethasone, betamethasone and triamcinolone. The usual methods for their technical production are based on microbiological hydroxylation at C,, and dehydration with cleavage of the 11-and l
A Novel Entry to the Taxane Structural Unit
β Scribed by Dipl.-Chem. Harribert Neh; Priv.-Doz. Dr. Siegfried Blechert; Dipl.-Chem. Wolfgang Schnick; Dipl.-Chem. Martin Jansen
- Publisher
- John Wiley and Sons
- Year
- 1984
- Tongue
- English
- Weight
- 233 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0044-8249
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## Abstract Warming the dilithium salt 7 of furanβ2,5βdicarboxaldehyde bis(tosylhydrazone) to 110Β°C and subsequently trapping the products in solid argon at 10 K resulted in the formation of 1βdiazoβhexβ3βenβ5βynβ2βone (9). The intermediate 2,5βbis(diazomethylfuran) (6) is too labile to be directly