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A novel dominant-negative mutant form of Epstein–Barr virus latent membrane protein-1 (LMP1) selectively and differentially impairs LMP1 and TNF signaling pathways

✍ Scribed by Adriaenssens, Eric; Mougel, Alexandra; Goormachtigh, Gautier; Loing, Estelle; Fafeur, Véronique; Auriault, Claude; Coll, Jean


Book ID
110068509
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
462 KB
Volume
23
Category
Article
ISSN
0950-9232

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Two genes encoding the latent membrane protein 1 (LMP1) of the Epstein-Barr virus (EBV) were isolated from a single case of Hodgkin's disease (HD) and were tested for their biological activities. The LMP1 gene from the Reed-Sternberg cells contained point mutations relative to the prototype LMP1 gen