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A novel determination method of the absolute configuration of 1-aryl-1-alkylalcohols and amines by an intramolecular CH/π shielding effect in 1H NMR

✍ Scribed by Masato Matsugi; Kinuyo Itoh; Masatomo Nojima; Yuri Hagimoto; Yasuyuki Kita

Book ID: 104231757
Publisher: Elsevier Science
Year: 2001
Tongue: French
Weight: 83 KB
Volume: 42
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)01709-9

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✦ Synopsis

A novel method for determination of the absolute configuration of various 1-aryl-1-alkylalcohols and amines was achieved by the observation of an intramolecular CH/p shielding effect in 1 H NMR. (S)-Isomer of the diastereomers always shows effective shielding effect.

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