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A novel cytopathic microtitre plate assay for hepatitis A virus and anti-hepatitis A neutralizing antibodies

✍ Scribed by L.P. Beales; D.J. Wood; P.D. Minor; J.A. Saldanha

Book ID
113256658
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
772 KB
Volume
59
Category
Article
ISSN
0166-0934

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Most hepatitis A virus (HAV) replication in cell culture has been reported to be nonlytic and relatively slow. A rapidly replicating isolate of strain HM-175 from persistently infected, serially passed cell cultures (pHM-175) was found to induce a cytopathic effect. This observation allowed the deve