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A novel convergent method for the synthesis of α-acyl-γ-hydroxylactams and its application in the total synthesis of PI-090 and 091

✍ Scribed by Hiromi Uchiro; Nobuhiro Shionozaki; Yu Kobayakawa; Hiroko Nakagawa; Kimiko Makino


Book ID
116318597
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
386 KB
Volume
22
Category
Article
ISSN
0960-894X

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Enantiomerically pure 1-chlorovinyl p-tolyl sulfoxides having two different substituents at the 2-position were synthesized from unsymmetrical ketones and (R)-(-)-chloromethyl p-tolyl sulfoxide in three steps. Treatment of the 1-chlorovinyl p-tolyl sulfoxides with cyanomethyllithium at -78°C to room