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A novel axially dissymmetric ligand with chiral 2,2,2-trifluoro-1-hydroxyethyl groups

✍ Scribed by Masaaki Omote; Akane Kominato; Michi Sugawara; Kazuyuki Sato; Akira Ando; Itsumaro Kumadaki

Book ID: 104261866
Publisher: Elsevier Science
Year: 1999
Tongue: French
Weight: 153 KB
Volume: 40
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(99)01083-7

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✦ Synopsis

Novel axially dissymmetric ligands (1) with two more chiral carbons were synthesized through homo-coupling of o-bromo-(R or S)-(2,2,2-trifluoro-l-acetoxyethyl)benzene. A high asymmetric induction was accomplished using 5 mol% of the Ti complex of this ligand for the reaction of benzaldehyde with Et2Zn giving 85% ee of 1-phenylpropanol in 97% isolation yield.

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