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A novel Aurora-A-mediated phosphorylation of p53 inhibits its interaction with MDM2

✍ Scribed by Hsueh, Kai-Wei; Fu, Shu-Ling; Chang, Chirn-Bin; Chang, Yu-Ling; Lin, Chao-Hsiung


Book ID
122476476
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
824 KB
Volume
1834
Category
Article
ISSN
1570-9639

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## Abstract Cross‐talk between the two transcription factors, p53 and hypoxia inducible factor 1Ξ± (HIF1A), is important in different pathophysiological conditions (Hammond and Giaccia, 2006, Clin Cancer Res 12:5007–5009) such as in the transition from myocardial hypertrophy to cardiac dilatation an