✦ LIBER ✦

A novel arylethynyltriazole acyclonucleoside inhibits proliferation of drug-resistant pancreatic cancer cells

✍ Scribed by Menghua Wang; Yi Xia; Yuting Fan; Palma Rocchi; Fanqi Qu; Juan L. Iovanna; Ling Peng

Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 767 KB
Volume: 20
Category: Article
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2010.08.093

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✦ Synopsis

Novel arylethynyltriazole acyclonucleosides were synthesized and assessed for their anticancer activity on drug-resistant pancreatic cancer MiaPaCa-2 cells. One lead compound was found to have much more potent apoptosis-related antiproliferative effects than gemcitabine, the current first-line treatment for pancreatic cancer. Further investigations showed that this active compound did not inhibit DNA synthesis, which means that it does not resemble gemcitabine and may involve a different mechanism of action.

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