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A novel approach to the enantioselective formal synthesis of pumiliotoxin 251D

โœ Scribed by Ni, Yike; Zhao, Gang; Ding, Yu


Book ID
120470414
Publisher
Royal Society of Chemistry
Year
2000
Weight
87 KB
Volume
19
Category
Article
ISSN
1472-7781

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An enantioselective synthesis of intermediates in syntheses of thienamycin (15) and epithienamycin-C (16) is described. Several years ago we reported that N-trimethylsilyl imines react with ester enolates to afford l-unsubstituted-B-lactams. 1 We also showed that ethyl B-hydroxybutyrate would serve