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A novel approach to ring A analogues of the marine pyridoacridine alkaloid ascididemin

✍ Scribed by Plodek, Alois; Raeder, Stephan; Bracher, Franz


Book ID
121276952
Publisher
Elsevier Science
Year
2013
Tongue
French
Weight
619 KB
Volume
69
Category
Article
ISSN
0040-4020

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Total synthesis of the marine pyridoacri
✍ Laurent Legentil; Jean Bastide; Evelyne Delfourne πŸ“‚ Article πŸ“… 2003 πŸ› Elsevier Science 🌐 French βš– 81 KB

The synthesis of the marine alkaloid sebastianine A and of a regioisomer has been accomplished via hetero-Diels-Alder reaction of indole-4,7-dione or N-tosylindole-4,7-dione with trifluoroacetamidocinnamaldehyde dimethylhydrazone, and subsequent cyclisation in alkaline conditions.