A novel approach to 4-benzylisoouinolines
โ Scribed by U. Berger; Th. Burgemeister; G. Dannhardt; K.K. Mayer; W. Wiegreb
- Book ID
- 103402484
- Publisher
- Elsevier Science
- Year
- 1984
- Tongue
- French
- Weight
- 464 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0040-4020
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๐ SIMILAR VOLUMES
## Abstract The reaction of 2โ(1โphenylvinyl)aniline and 4โchloroโ2โ(1โphenylvinyl)aniline with acetophenone derivatives, 1โ(naphthalenโ1โyl)ethanone and 1โ(furanโ2โyl)ethanone in toluene at 110โ115ยฐ with tolueneโ4โsulfonic acid as a catalyst leads in goodโtoโexcellent yields to the 2,2โdisubstitut
The viability of the key steps in our approach to the novel sesquiterpene breynolide (1) has hem verified by preparation of the hydrobenzothiophene 16. The sequence features a Diels-Alder reaction of 10 with 7 to load eventually to 13; subsequent dipolar cycloaddition of 13 with a functionalized nit