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A Novel Antioxidant Function for the Tumor-Suppressor Gene p53 in the Retinal Ganglion Cell

โœ Scribed by O'Connor, J. C.; Wallace, D. M.; O'Brien, C. J.; Cotter, T. G.


Book ID
126706077
Publisher
Association for Research in Vision and Ophthalmology
Year
2008
Tongue
English
Weight
396 KB
Volume
49
Category
Article
ISSN
0020-9988

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In this study, we analyzed 10 human squamous cell carcinomas (SCCs) for alterations in the p53 tumor suppressor gene in exons 4 through 9 by single-strand conformation polymorphism (SSCP) analysis. We found that 2 of 10 SCCs displayed unusual SSCP alleles at exon 7 of the p53 gene. Subsequent clonin