A novel and simplified route to the synthesis of N3S chelators for 99mTc labeling
β Scribed by Z Zhu; Y Wang; Y Zhang; G Liu; N Liu; M Rusckowski; D.J Hnatowich
- Book ID
- 117687745
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 206 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0969-8051
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π SIMILAR VOLUMES
The synthesis of two new N 2 S 2 or N 2 SO tetradentate ligands and the preparation of their technetium-99m complexes are reported. Each ligand leads to a unique 99m Tc-complex with an excellent radiochemical yield. The in vivo stability of these complexes was determined by serum stability and cyste
## Abstract __Overexpression of the gastrinβreleasing peptide receptor (GRPR) in a variety of human carcinomas has provided a means of diagnosis and treatment. Previously we reported a metabolically stable (__N__^Ξ±^His)AcβΞ²AlaβΞ²Alaβ[Cha^13^,Nle^14^]BBS(7β14) analogue with high affinity for the GRPR