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A Novel and Highly Efficient Synthesis of gem -Difluorocyclopropanes

โœ Scribed by Tian, Feng; Kruger, Virginie; Bautista, Olivia; Duan, Jian-Xin; Li, An-Rong; Dolbier,, William R.; Chen, Qing-Yun


Book ID
121335047
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
93 KB
Volume
2
Category
Article
ISSN
1523-7060

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Regio- and stereoselective synthesis of
โœ Takeo Taguchi; Hirofumi Sasaki; Akira Shibuya; Tsutomu Morikawa ๐Ÿ“‚ Article ๐Ÿ“… 1994 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 292 KB

## Regio-and stereoselective formation of the finctionalized gem-dt@orocyclopropane derivative was achieved through the Michael aakiition of lithium enolate of ester or amide with 4bromo-4.4-difluorocrotonate I followed by the triethylborane-02 mediated intramolecular substihction reaction. Cyclop