A novel and general route to diverse A-ring aromatic trichothecanes via cyclobutanes
β Scribed by Hideo Nemoto; Junji Miyata; Keiichiro Fukumoto
- Book ID
- 107857908
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- French
- Weight
- 723 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0040-4020
No coin nor oath required. For personal study only.
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Total synthesis of 4-deoxyverrucarol (4), a trichothecane-type sesquiterpene was achieved via two types of ring expansion reaction, 1,2-rearrangement of 18 and palladium mediated ring expansion reaction of 20, as key steps providing a new route to trichothecanes.
A recent report from this laboratory disclosed an extremely efficient preparation of cyclopropanone dithioketals by treatment of dithioacetals containing a 3-phenylthio substituent with methyllithium in tetrahydrofuran (THF) containing tetramethylethylenediamine (TMEDA) at O'C. 1 We now report that