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A novel and facile reaction to N6-alkylated adenosine via benzotriazole as a synthetic auxiliary

✍ Scribed by Hanan M. N. M. Afify; Erik B. Pedersen; Magdy A. Zahran

Publisher
Journal of Heterocyclic Chemistry
Year
2000
Tongue
English
Weight
221 KB
Volume
37
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

The reaction of benzotriazole with aliphatic, aromatic or heteroaromatic aldehyde and adenosine leads to a benzotriazole adduct which is reduced with sodium borohydride to the corresponding N^6^‐alkylated adenosine derivatives. This procedure is also utilized in a new route to N^6^‐(3‐iodobenzyl)adenosine‐5′‐N‐methyluronamide (IB‐MECA) which is considered an important adenosine agonist at A~3~ adenosine receptors.

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