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A novel and efficient method for the synthesis of 5-arylnaphtho[2,1-c][2,7]naphthyridine derivatives catalyzed by iodine

✍ Scribed by Xiang-Shan Wang; Qing Li; Jian-Rong Wu; Chang-Sheng Yao; Shu-Jiang Tu

Publisher
Journal of Heterocyclic Chemistry
Year
2009
Tongue
English
Weight
101 KB
Volume
46
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

magnified image A novel method for the synthesis of 1,2‐dihydro‐5‐arylnaphtho[2,1‐c][2,7]naphthyridine derivatives via a three‐component reaction of aromatic aldehyde, naphthalen‐2‐amine, and N‐substituted piperidin‐4‐one derivatives is described using 5 mol % iodine as catalyst. The features of this new procedure are mild reaction condition, high yield, operational simplicity, and uses available reactants. J. Heterocyclic Chem., (2009).

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