An efficient and highly selective method for the synthesis of cryptotackiene derivatives catalyzed by iodine

✍ Scribed by Xiang-Shan Wang; Jie Zhou; Ming-Yue Yin; Ke Yang; Shu-Jiang Tu

• Publisher: Journal of Heterocyclic Chemistry
• Year: 2010
• Tongue: English
• Weight: 198 KB
• Volume: 47
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.404

✦ Synopsis

Abstract

magnified image A mild, efficient and highly selective approach to the synthesis of cryptotackiene derivatives via three‐component reactions of 3‐amino‐9‐ethylcarbazole and aromatic aldehydes with electron‐rich alkenes, such as 2,3‐dihydrofuran, or 3,4‐dihydro‐2__H__‐pyran catalyzed by iodine in THF is reported. It is worth to note that only trans‐products were obtained with high selectivity in good to high yields, which confirmed by X‐ray diffraction analysis. J. Heterocyclic Chem., (2010).