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A novel and convenient method for synthesis of carbamoyl and thiocarbamoyl phosphonates

✍ Scribed by Babak Kaboudin; Hazegh Zahedi

Book ID
102232940
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
76 KB
Volume
20
Category
Article
ISSN
1042-7163

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✦ Synopsis

A simple, efficient, and general method has been developed for the synthesis of carbamoyl and thiocarbamoyl phosphonic esters using CaCl 2 as an efficient Lewis base catalyst. Carbamoyl and thiocarbamoyl phosphonic esters were obtained in good yield (37%-65%) and purity under mild conditions by the reaction of diethyl phosphite with isocyanates and isothiocyanates in the presence of CaCl 2 . This method is easy, rapid, and good-yielding reaction for the synthesis of carbamoyl and thiocarbamoyl phosphonic esters.

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