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A Convenient Synthesis of Aryl-Substituted N-Carbamoyl/N-Thiocarbamoyl Narcotine and Related Compounds

✍ Scribed by Shefali Aggarwal; Narendra N. Ghosh; Ritu Aneja; Harish Joshi; Ramesh Chandra

Publisher
John Wiley and Sons
Year
2002
Tongue
German
Weight
87 KB
Volume
85
Category
Article
ISSN
0018-019X

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✦ Synopsis

The reaction of nornarcotine and 5-bromonornarcotine, synthesized from noscapine, with suitable aromatic isocyanates or isothiocyanates provides a general method for the synthesis of aryl-substituted N-carbamoyl or N-thiocarbamoylnarcotine and related compounds. Similarly, 15a has been prepared via the reduction of the lactone ring moiety of noscapine. Also, an improved procedure, which utilizes narcotine N-oxide ¥ HCl for generation of nornarcotine, is described.

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