A Novel Amination Reaction of Carboxylic Acid Derivatives with Tetrakis(dimethylamino)titanium
β Scribed by Weingarten, Harold; White, William A.
- Book ID
- 127316935
- Publisher
- American Chemical Society
- Year
- 1966
- Tongue
- English
- Weight
- 109 KB
- Volume
- 88
- Category
- Article
- ISSN
- 0002-7863
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π SIMILAR VOLUMES
## Abstract The reaction of enolates of Ξ±βunsubstituted carboxamides 3 with diphenyl phosphorazidate (DPPA) and di(__tert__βbutyl) dicarbonate (βBoc anhydrideβ) in THF at β78Β° yielded 2β{[(__tert__βbutoxy)carbonyl]amino}carboxamides 5 (__Scheme 2__) which are derivatives of Ξ±βamino acids. In this r
Carboxylic acids react with 2 equivalents of diethyl phosphorocyanidate in the presence of triethylamine to give dicyanophosphates in good yields; these dicyanophosphates can be hydrolyzed easily to give homologated ~t-hydroxycarboxylic acids.