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A Novel Activating Mutation of the K-ras Gene in Human Primary Colon Adenocarcinoma

โœ Scribed by Kazunori Tsukuda; Motohiko Tanino; Hiroyuki Soga; Nobuyoshi Shimizu; Kenji Shimizu


Book ID
115586919
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
241 KB
Volume
278
Category
Article
ISSN
0006-291X

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## Abstract Experimental models indicate that activated ras genes and HPV oncogenic sequences may cooperate in inducing a completely transformed phenotype in epithelial cells. We searched for Kโ€__ras__ gene mutations and HPV typeโ€16 and โ€18 sequences in 67 primary adenocarcinomas of the uterine cer