Some forms of familial Alzheimer disease (FAD) have shown linkage to DNA probes for the loci D21S1 and D21S16 on chromosome 21. To investigate the physical location of these DNA probes, we have constructed a physical map of this region of chromosome 21 by using quantitative Southern blot analysis of
A Notl restriction map of the entire long arm of human chromosome 21
โ Scribed by Ichikawa, Hitoshi; Hosoda, Fumie; Arai, Yasuhito; Shimizu, Kimiko; Ohira, Miki; Ohki, Misao
- Book ID
- 109916645
- Publisher
- Nature Publishing Group
- Year
- 1993
- Tongue
- English
- Weight
- 529 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1061-4036
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Cytogenetic and molecular genetic analyses have shown that a tumor-suppressor gene for human meningioma is located on the long arm of chromosome 22. Recently, somatic mutations of the NF2 gene have been identified in sporadic meningiomas. However, tumorigenesis of certain cases of meningioma cannot
An (AC)n repeat within the anonymous DNA sequence D21S171 was shown to be highly polymorphic in members of the 40 Centre d'Etude du Polymorphisme Humaine (CEPH) families. Ten different alleles at this marker locus were detected by electrophoresis on polyacrylamide gels of DNA amplified by the polyme
Von Hippel-Lindau disease is a heritable tumour syndrome caused by the loss of the function of a tumour suppressor gene on the short arm of human chromosome 3. The interval RAF1-D3S18 (3p25-3p26) has been identified by genetic linkage studies to harbour the von Hippel-Lindau gene. We have constructe