## By DONALD F. WALKER HE PUBLICATION of clinical experience with in 25 ml. of anhydrous ethanol and treated with 5.3 ethyl vanillate in cases of disseminated histoml. of ethanolic ammonia (0.17 Gm.). A granular plasmosis (1) attracted attention to the desirability tan solid separated on standing
A Note on the Preparation of 4-Chloro-2-isopropyl-5-methylphenoxyacetamidine Hydrochloride
โ Scribed by Walker, Donald F.
- Publisher
- Elsevier
- Year
- 1956
- Weight
- 103 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0095-9553
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## Abstract 7โChloroโ5โ(2โchlorophenyl)โ1,3โdihydroโ2Hโ1,4โbenzodiazepinโ2โone labeled with carbonโ14 in carbon 5 of the diazepine ring has been synthesized. The compound was prepared in a multistep synthesis from barium carbonateโ^14^C in an overall yield of 23%.
## Abstract The title compound (1) was synthesized by a 7โstep sequence. 4โAminoโ2โhydroxyโ[carbonylโ^14^C]benzoic acid (1) was selectively methylated to provide the ether ester 2, which was smoothly chlorinated in acetic acid to give 3. The ester was hydrolyzed with aqueous potassium hydroxide to