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A Useful Modification of the Evans Auxiliary: 4-Isopropyl-5,5-diphenyloxazolidin-2-one

โœ Scribed by Tobias Hintermann; Dieter Seebach


Publisher
John Wiley and Sons
Year
1998
Tongue
German
Weight
529 KB
Volume
81
Category
Article
ISSN
0018-019X

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N-Allyl, N-cinnamyl, and N-(3-trimethylsilyl)propargyl derivatives of 4-isopropyl-5,5-diphenyloxazolidin-2-one (DIOZ) are prepared by lithiation of the parent DIOZ (with BuLi in THF) and reaction with the corresponding bromides (Scheme 1). Lithiation in the same solvent, with deprotonation by BuLi o