✦ LIBER ✦

A newly synthesized, potent tyrosinase inhibitor: 5-(6-Hydroxy-2-naphthyl)-1,2,3-benzenetriol

✍ Scribed by Jehun Choi; Sung Jin Bae; Young Mi Ha; Jae Kyung No; Eun Kyeong Lee; Jun Sik Lee; Suhee Song; Hyojin Lee; Hongsuk Suh; Byung Pal Yu; Hae Young Chung

Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 351 KB
Volume: 20
Category: Article
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2010.06.087

No coin nor oath required. For personal study only.

✦ Synopsis

In searching for new agents with a depigmenting effect, we synthesized a derivative of resveratrol, 5-(6-hydroxy-2-naphthyl)-1,2,3-benzenetriol (5HNB) with a potent tyrosinase inhibitory activity.

5HNB inhibited mushroom tyrosinase with an IC 50 value of 2.95 lM, which is more potent than the well-known anti-tyrosinase activity of kojic acid (IC 50 = 38.24). The results of the enzymatic inhibition kinetics by Lineweaver-Burk analysis indicated 5HNB inhibits tyrosinase non-competitively when

📜 SIMILAR VOLUMES

Corrigendum to “A newly synthesized, pot

Corrigendum to “A newly synthesized, potent tyrosinase inhibitor: 5-(6-Hydroxy-2-naphthyl)-1,2,3-benzenetriol” [Bioorg. Med. Chem. Lett. 20 (2010) 4882–4884]

✍ Jehun Choi; Sung Jin Bae; Young Mi Ha; Jae Kyung No; Eun Kyeong Lee; Jun Sik Lee 📂 Article 📅 2011 🏛 Elsevier Science 🌐 English ⚖ 139 KB

The authors regret that this article contains one error. The structure of Kojic acid (4) was revised. Therefore, the following correction should be made.

1-Substituted-2,6,6-trimethyl-3-(1-oxo-3

1-Substituted-2,6,6-trimethyl-3-(1-oxo-3-hydroxy-5,5-dimethyl-2-cyclohexen-2-yl)-4-oxo-4,5,6,7-tetrahydroindoles: a novel class of potent hypoglycemic agents

✍ K Nagarajan; P.K Talwalker; S.J Shenoy 📂 Article 📅 1988 🏛 Elsevier Science 🌐 French ⚖ 338 KB

ChemInform Abstract: Design, Synthesis a

ChemInform Abstract: Design, Synthesis and Discovery of 1-(2-(6-Chloro-3-methylsulfonyl)-naphthyl)-1H-pyrazole-5-carboxylamides as Highly Potent Factor Xa Inhibitors.

✍ Zhaozhong Jon Jia; Robert Murry Scarborough; Penglie Zhang; Sherin Halfon; Ann E 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 34 KB 👁 1 views

Syntheses of isotopically labeled 4-[1-(

Syntheses of isotopically labeled 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethenyl]benzoic acid (LGD1069), a potent retinoid x receptor-selective ligand

✍ Lin Zhang; Beth Ann Badea; Debra Enyeart; Elaine M. Berger; Dale E. Mais; Marcus 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 French ⚖ 576 KB

## Abstract LGD1069, 4‐[1‐(3,5,5,8,8‐pentamethyl‐5,6,7,8‐tetrahydro‐2‐naphthyl)ethenyl] benzoic acid, is the first retinoid X receptor (RXR) selective retinoid to enter clinical trials for treatment of dermatological diseases and cancer. In order to examine biological properties such as receptor bi

ChemInform Abstract: 4-(1,1-Dioxo-1,4-di

ChemInform Abstract: 4-(1,1-Dioxo-1,4-dihydro-1λ6-benzo [1,4]thiazin-3-yl)-5-hydroxy-2H-pyridazin-3-ones as Potent Inhibitors of HCV NS5B Polymerase.

✍ Chinh V. Tran; et al. et al. 📂 Article 📅 2008 🏛 John Wiley and Sons ⚖ 24 KB 👁 1 views

Inhibitors of HMG-CoA reductase. Biologi

Inhibitors of HMG-CoA reductase. Biological effects of A 6-[2-[2-(4-fluoro-3-methylphenyl)-4-substituted cyclohexe-1-en-1-yl]ethenyl]-4-hydroxy-3,4,5,6-tetrahydro-2h-pyran-2-one

✍ JR Regan; JG Bruno; K Gustafson; D Amin; K Neuenschwander; M Perrone 📂 Article 📅 1992 🏛 Elsevier Science 🌐 French ⚖ 903 KB