A newEcoRI polymorphism at the D21S13 locus

✍ Scribed by S. -M. Pulst; J. R. Korenberg; J. Greenwald; M. Carbone

• Book ID: 104666303
• Publisher: Springer
• Year: 1990
• Tongue: English
• Weight: 136 KB
• Volume: 84
• Category: Article
• ISSN: 0340-6717
• DOI: 10.1007/bf00210815

✦ Synopsis

The D21S13 locus has shown linkage to a gene for familial Alzheimer disease (FAD) on chromosome 21 (St. George-Hyslop et al. 1987). The limited informativeness of probes for this locus have hindered precise mapping of the FAD locus and analysis of nonallelic heterogeneity in FAD (Schellenberg et al. 1988; St. George-Hyslop et al. 1987). We describe a new EcoRI polymorphism at the D21S13 locus that may be useful for the further study of FAD families.