𝔖 Bobbio Scriptorium
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A new versatile synthesis of 4-substituted diaminopyridine derivatives

✍ Scribed by Sumela Banerjee; Brigitte Voit; Gert Heinrich; Frank Böhme


Book ID
113930650
Publisher
Elsevier Science
Year
2012
Tongue
French
Weight
221 KB
Volume
53
Category
Article
ISSN
0040-4039

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✍ Nicolas Bensel; David Lagnoux; Verena Niggli; Markus Wartmann; Jean-Louis Reymon 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 German ⚖ 155 KB

## Abstract Electrophilic alkylation of colchicine at C(4) was accomplished by a multicomponent aromatic electrophilic substitution reaction with electrophilic aldehydes and carboxylic acids or amides in H~2~SO~4~. A series of new derivatives were obtained and evaluated for their antiproliferative