New C(4)-Functionalized Colchicine Deriv
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Nicolas Bensel; David Lagnoux; Verena Niggli; Markus Wartmann; Jean-Louis Reymon
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Article
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2004
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John Wiley and Sons
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German
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## Abstract Electrophilic alkylation of colchicine at C(4) was accomplished by a multicomponent aromatic electrophilic substitution reaction with electrophilic aldehydes and carboxylic acids or amides in H~2~SO~4~. A series of new derivatives were obtained and evaluated for their antiproliferative