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A new translocation t(9;11)(q34;p15) fuses NUP98 to a novel homeobox partner gene, PRRX2, in a therapy-related acute myeloid leukemia

✍ Scribed by Gervais, C; Mauvieux, L; Perrusson, N; Hélias, C; Struski, S; Leymarie, V; Lioure, B; Lessard, M

Book ID: 110056089
Publisher: Nature Publishing Group
Year: 2004
Tongue: English
Weight: 498 KB
Volume: 19
Category: Article
ISSN: 0887-6924
DOI: 10.1038/sj.leu.2403565

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The nucleoporin gene NUP98 has been reported to be fused to 9 partner genes in hematologic malignancies with 11p15 translocations. The NUP98-HOXA9 fusion gene has been identified in acute myeloid leukemia (AML) and chronic myelogenous leukemia with t(7;11)(p15;p15). We report here a novel NUP98 part