A New Tetracyclic Ring System of Biological Interest. Indolo[3,2-e][1,2,3]triazolo[1,5-a]pyrimidines through Domino Reactions of 2-Azidoindole
β Scribed by Maria Almerico, Anna; Lauria, Antonino; Patella, Chiara; Diana, Patrizia; Barraja, Paola; Montalbano, Alessandra; Cirrincione, Girolamo; Dattolo, Gaetano
- Book ID
- 121704769
- Publisher
- Japan Institute of Heterocyclic Chemistry
- Year
- 2003
- Tongue
- English
- Weight
- 106 KB
- Volume
- 60
- Category
- Article
- ISSN
- 0385-5414
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## Abstract Derivatives of the new ring system pyrrolo[3,4β__e__][1,2,3] triazolo[1,5β__a__]pyrimidine **6** were prepared in high yields in one step by reaction of 3βazidopyrrole **3** and substituted acetonitriles. Compound **6b** rearranged, upon heating in dimethyl sulfoxide in the presence of
Derivatives of the new ring system pyrazolo [3,4-d][1,2,3]triazolo[1,5-a]pyrimidine were synthesized from the corresponding angular isomers, through a Dimroth rearrangement, in quantitative yields. Preliminary computational studies demonstrated that this class of compounds could be a good candidate