✦ LIBER ✦

A new synthetic route to tropane alkaloids. Pseudotropine and tropacocaine

✍ Scribed by Hideo Iida; Yohya Watanabe; Chihiro Kibayashi

Book ID: 104242319
Publisher: Elsevier Science
Year: 1984
Tongue: French
Weight: 227 KB
Volume: 25
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)91127-x

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✦ Synopsis

Pseudotropine and tropacocaine have been synthesized by a facile route involving the [4 + 21 nitroso cycloaddition followed by interna1 Sn2 displacement. The tropane class of alkaloids have continued to elicit the unabated interests among organic chemists because of their pharmacological significance, and a great deal of work has been done on the stereochemical and synthetic problems.

1 Since a superb approach to tropinone (1) was devised by Robinson, 2

a number of syntheses of some tropanes have been reported.

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