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A new synthesis of α-amino acids—III: Amidoalkylation of active methylene compounds with glyoxylic acid derivatives

✍ Scribed by D. Ben-Ishai; J. Altman; Z. Bernstein; N. Peled


Publisher
Elsevier Science
Year
1978
Tongue
French
Weight
845 KB
Volume
34
Category
Article
ISSN
0040-4020

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## Abstract The reaction of enolates of α‐unsubstituted carboxamides 3 with diphenyl phosphorazidate (DPPA) and di(__tert__‐butyl) dicarbonate (‘Boc anhydride’) in THF at −78° yielded 2‐{[(__tert__‐butoxy)carbonyl]amino}carboxamides 5 (__Scheme 2__) which are derivatives of α‐amino acids. In this r