A New Synthesis of Tanikolide.
β Scribed by Hongbin Zhai; Qingshou Chen; Jingrui Zhao; Shengjun Luo; Yueshun Jia
- Publisher
- John Wiley and Sons
- Year
- 2003
- Weight
- 112 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0931-7597
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## Abstract The Ξ΄βlactoneβcontaining natural product (+)βtanikolide, a brine shrimp toxin and antifungal compound, was synthesized in nine steps with an overall yield of 26.4β% by employing Sharpless asymmetric epoxidation and ZrCl~4~βcatalyzed intramolecular acetalization as the key steps. The nov
## Abstract For Abstract see ChemInform Abstract in Full Text.
Asymmetric transformations of 1,1-disubstituted alkenes provide important building blocks for chemical synthesis, but are often plagued with low stereoselectivities because it can be difficult for a chiral reagent or catalyst to discriminate between the enantiotopic faces of these substrates. [1] Am