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A New Synthesis of Optically Active 3-Substituted (3S)-3,4-Dihydro-5-(perfluoroalkyl)-2H-[1,4]oxazepin-7-ones

✍ Scribed by Sébastien Richard; Gildas Prié; Alain Guignard; Jérôme Thibonnet; J.-Luc Parrain; Alain Duchêne; Mohamed Abarbri

Publisher
John Wiley and Sons
Year
2003
Tongue
German
Weight
93 KB
Volume
86
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

Optically active (perfluoroalkyl)‐oxazepin‐7‐ones were synthesized in two steps starting from ethyl perfluorobut‐2‐ynoate by direct addition of optically active amino alcohols via intermolecular Michael addition and lactone formation.

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