A new synthesis of islandicin and cynodontin
โ Scribed by Neelakantan, S. ;Rajagopalan, T. R. ;Seshadri, T. R.
- Book ID
- 112981225
- Publisher
- Springer-Verlag
- Year
- 1959
- Tongue
- English
- Weight
- 399 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0370-0089
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This communication describes a solution to the general problem of the regiospecific synthesis of an unsymmetrically substituted anthraquinone system. Acetogenins containing this moiety are frequently encountered as antibiotics,' and the system is characteristic of the clinically important anthracycl
The synthesis of anthraquinones i and its higher homologs is generally accomplished by the two-step double acylation of aromatic substrates with phthalic anhydrides under Friedel-Crafts conditions (Scheme I). However the method has two drawbacks. It lacks ## --.' -* This work and some of the resu