## Abstract Tissue temperature is a fundamental physiological parameter that can provide insight into pathological processes. The purpose of this study was to develop and characterize a novel paramagnetic chemical exchange saturation transfer (CEST) agent suitable for in vivo temperature mapping at
✦ LIBER ✦
A new synthesis of cystamine modified Eu3+ DOTAM-Gly-Phe-OH: a conjugation ready temperature sensitive MRI contrast agent
✍ Scribed by Suchý, Mojmír; Li, Alex X.; Bartha, Robert; Hudson, Robert H. E.
- Book ID
- 118738601
- Publisher
- Royal Society of Chemistry
- Year
- 2008
- Tongue
- English
- Weight
- 243 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1477-0520
- DOI
- 10.1039/B808282K
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A cell penetrating peptide conjugate and dimeric PARACEST MRI contrast agents, based on the DOTAM-Gly-L-Phe-OH scaffold have been prepared in moderate yields using diethyl azodicarboxylate (DEAD) or iodine-mediated disulfide bridge formation as a key step. Magnetic (PARACEST) properties of these age