𝔖 Bobbio Scriptorium
✦   LIBER   ✦

A new synthesis of 4-amino-2-quinolinones

✍ Scribed by Jan Bergman; Anna Brynolf; Eino Vuorinen

Publisher
Elsevier Science
Year
1986
Tongue
French
Weight
603 KB
Volume
42
Category
Article
ISSN
0040-4020

No coin nor oath required. For personal study only.

✦ Synopsis

Addition of Crignard or organolithium reagents to R-(a-haloacyl)-g-alkylsubstituted anthranilonitriles (e.g. B-(2-bromopropionyl)-N-methyl-2-cyanoaniline) induced anion formation followed by cyclization to I-amino-2quinolinones (e.g. I-amino-1,3-dimethyl-2-quinolinone (1Q)). Substrates lacking a-hydrogen atoms, such as p-(a-bromoisobutyryl)-2_cyanoaniline, also yielded 3,3-dimethylquinolinedione (B) by cyclization.

In these cases the initial step is a halogen-metal exchange reaction.

📜 SIMILAR VOLUMES

Synthesis of N-Amino-3-hydroxy-2-phenyl-
Synthesis of N-Amino-3-hydroxy-2-phenyl-4(1H)-quinolinone.
✍ Lucie Spacilova; Jan Hlavac; Pavel Hradil; Iveta Frysova; Michal Malon; Miroslav 📂 Article 📅 2006 🏛 John Wiley and Sons ⚖ 16 KB 👁 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

Synthesis of N-amino-3-hydroxy-2-phenyl-
Synthesis of N-amino-3-hydroxy-2-phenyl-4(1H)-quinolinone
✍ Lucie Spáčilová; Jan Hlaváč; Pavel Hradil; Iveta Fryšová; Miroslav Soural; Petr 📂 Article 📅 2006 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 132 KB 👁 1 views

## Abstract magnified image 2‐[(Disubstituted‐methylene)‐hydrazino] benzoic acid phenacylesters **2a‐2d**, prepared from anthranilic acid phenacylester **1**, were unsuccesfully tried as starting materials for the synthesis of __N__‐amino‐3‐hydroxy‐2‐phenyl‐4(1__H__)‐quinolinone **8**. The desired

Synthesis of 2-amino-1,4-dihydro-4-quino
Synthesis of 2-amino-1,4-dihydro-4-quinolinones and diaminomethylene meldrum's acids derivatives as potential potassium channel openers
✍ Béanéadicte Erb; Benoît Rigo; Bernard Pirotte; Daniel Couturier 📂 Article 📅 2002 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 158 KB

## Abstract Starting from 5‐bismethylthiomethylene Meldrum's acid, the synthesis of 5‐diaminomethylene Meldrum's acids and 2‐aminoquinolone derivatives, structurally related to potassium channels openers pinacidil and diazoxide, is described.

A new synthesis of 3-amino-2-alkenoates
A new synthesis of 3-amino-2-alkenoates
✍ Tamejiro Hiyama; Kazuhiro Kobayashi 📂 Article 📅 1982 🏛 Elsevier Science 🌐 French ⚖ 229 KB

Dedicated to Professor Hitosi Nozaki on the occasion of his 60th birthday. Magnesium enolates of t-butyl (or ethyl) acetate and t-butyl propionate are found to react with nitriles to give 3-amino-2-alkenoates having Z configuration. The title compounds are versatile intermediates for the synthesis