An expeditious and concise synthesis of 3-(difluoromethoxy)-5,6,7,8-tetrahydro-1,6-naphthyridine and 3-(trifluoromethoxy)-5,6,7,8-tetrahydro-1,6-naphthyridines is described. Starting from N-benzyl piperidone, the key intermediates leading to these two biologically desirable synthones were rapidly as
✦ LIBER ✦
A new synthesis of 3-(trifluoromethoxy) aniline
✍ Scribed by Bernard Langlois; Gérard Soula
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- English
- Weight
- 41 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0022-1139
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## Abstract Synthesis of a carbon‐14 labeled trifluoromethoxy group has been accomplished using the stepwise oxidative fluorination–desulfurization of a readily prepared [^14^C]xanthate (**5**). This novel labeling procedure allowed a rapid synthesis of substance P antagonist candidate **1** that a