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A new structural class of serine protease inhibitors revealed by the structure of the hirustasin–kallikrein complex

✍ Scribed by Peer RE Mittl; Stefania Di Marco; Gabriele Fendrich; Gabriele Pohlig; Jutta Heim; Christian Sommerhoff; Hans Fritz; John P Priestle; Markus G Grütter


Book ID
114329461
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
767 KB
Volume
5
Category
Article
ISSN
0969-2126

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✍ Patricia A. McDonnell; Gary W. Caldwell; Gregory C. Leo; Brent L. Podlogar; Bruc 📂 Article 📅 1997 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 99 KB 👁 2 views

The nmr solution conformation of cyclotheonamide A (CtA) was determined in aqueous media. The data produced 15 distance and 10 torsional constraints which were used to generate conformations using restrained simulated annealing (SA) and distance geometry/simulated annealing (DG/SA) calculations. Two