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Structure of the Human Cytomegalovirus Protease Catalytic Domain Reveals a Novel Serine Protease Fold and Catalytic Triad

โœ Scribed by Ping Chen; Hideaki Tsuge; Robert J. Almassy; Cindy L. Gribskov; Susumu Katoh; Darin L. Vanderpool; Stephen A. Margosiak; Christopher Pinko; David A. Matthews; Chen-Chen Kan


Book ID
117267170
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
842 KB
Volume
86
Category
Article
ISSN
0092-8674

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โœ Jun Nishihira; Hiroto Tachikawa ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 160 KB

Serine and cysteine proteases are structurally distinct families of proteolytic enzymes that exert analogous catalytic reactions. It is known that serine, histidine, and aspartate residues are involved in a putative catalytic triad of serine proteases whereas cysteine, histidine and aspartate (or as