A new stereoselective route to (2S, 3S, 8S, 9S, 4E, 6E)-3-amino-9-methoxy-2, 6, 8-trimethyl-10-phenyldeca-4, 6-dienoic acid (Adda)
✍ Scribed by Hong Yong Kim; Peter L. Toogood
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- French
- Weight
- 189 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
The chiral aldehyde 7 was prepared by diastereoselective alkylation, subsequent 1,2addition of isopropenylmagnesium bromide gave rise to a mixture (68:32) of the allylic alcohols 8 and 10 which was separated by recycling MPLC. Claisen rearrangement of the propionates of
Bis( 1'-h ydrox y met h y le t hyl)-6,14-dimet hy1-8,16-dioxa-2,4,10,12-cyclohexadecatetraene-1,9-dione. -A Building Block for the Synthesis of Elaiophylin
## Abstract Cyclization of ethyl (__E__)/(__Z__)‐[2‐(1‐cyclohexen‐1‐yl)cyclohexylidene]cyanoacetate (2) in cold concentrated sulfuric acid affords 10‐amino‐1,2,3,4,5,6,7,8‐octahydrophenanthrene‐9‐carboxylic acid (4) and 3,5,6,7,8,8a‐hexahydro‐3‐oxospiro‐[1__H__‐2‐benzopyran‐1,1′‐cyclohexane]‐4‐carb