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A new single-nucleotide polymorphism in the seventh component of complement (C7) gene

✍ Scribed by Mayumi Nakagawa; I. Yuasa; Kazuo Umetsu; Yoshito Irizawa

Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
87 KB
Volume
44
Category
Article
ISSN
1435-232X

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A C7 cDNA probe detecting a TaqI restriction fragment length polymorphism has been used to examine the segregation of the "silent allele" (C7\*Q0) in two familial deficiencies. Carrier diagnosis in healthy children is possible when both parents are heterozygotes. Only one of these two families was i

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Using polyacrylamide gel isoelectric focusing and standard specific hemolytic detection methods, genetic polymorphisms have been found in the sixth and seventh complement components (C6 and C7) in two laboratory groups of Common marmosets. The C6 locus is highly variable and the products of six alle