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A new route to pyrimido[1,6-a]benzimidazole derivatives

✍ Scribed by M. Bakavoli; M. Rahimizadeh; A. R. Ebrahimi; A. Taghizadeh; A. Davoodnia; M. Nikpour

Publisher
Journal of Heterocyclic Chemistry
Year
2008
Tongue
English
Weight
280 KB
Volume
45
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

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Cyclocondensation of orthophenylendiamines with 3‐bromopropionic acid in PPA afforded 2‐vinylbenzimidazoles which were subsequently converted to their corresponding 2‐(1,2‐dibromoethyl)‐1__H__‐benzimidazoles on treatment with bromine. Reaction of these compounds with aryl nitriles or aryl isocyanates in basic chloroform yielded 1‐arylpyrimido[1,6‐a]benzimidazoles and 2‐arylpyrimido[1,6‐a]‐benzimidazol‐3‐ones respectively.

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