Several new pyrimido[ 1,2-albenzimidazole derivatives were synthesized by reacting 2-aminobenzimidazole with u, p-unsaturated nitriles and benzoylacetonitrile derivatives. The structures of the products were established on the basis of elemental analyses, IR and 'H-NMR spectral data.
Umsetzungen mit 2-Aminobenzimidazol: Synthese einiger neuer Pyrimidd 1,2-albenzimidazol-Derivate
Mehrere neue Pyrimidol1,2-albenzimidazole Derivate wurden durch Reaktionen von 2-Aminobenzimidazol mit u, P-ungesΓ€ttigten Nitrilen und Benzoyiacetonitril-Derivaten synthetisiert. Die Strukturen der neuen Derivate wurden anhand der Elementaranalyse, der IR-und 'H-NMR-Spectren identifiziert.
The incorporation of an imidazole nucleus, a biologically accepted pharmacophore, in the benzimidazole nucleus has made it a versatile heterocycle possessing a wide spectrum of biological activities. In addition, a large variety of substituted 2-aminobenzimidazoles have been found to possess in vivo and in vitro growth inhibitory activity against various strains of bacteria, fungi and viruses. Moreover, several 1and 1,3-disubstituted benzimidazoles and pyrimido[1,2-a]benzimidazoles are known to exhibit CNS depressant, anti-inflammatory, antithyroid and cardiovascular activitiesl). The above mentioned biological and medicinal activities of benzimidazoles and related compounds prompted our interest for the synthesis of severai new derivatives of these ring systems. The reactions of 2-aminobenzimidazole (1) with a, 0-unsaturated nitriles and benzoylacetonitrile derivatives (2) seemed to US to be a soie, easy and facile route for the synthesis of these derivatives.