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A new route to 4-, 5-, and 6-indolecarboxylic acids

โœ Scribed by Kasahara, Akira; Izumi, Taeko; Yanai, Hiroshi; Murakami, Satoshi; Takatori, Masayuki


Book ID
121748750
Publisher
Wiley (John Wiley & Sons)
Year
2007
Tongue
English
Weight
133 KB
Volume
36
Category
Article
ISSN
0268-2575

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The title compounds are prepared in one step from ester enolates and 3,3,3-trifluoropropene. The a-substituted 5,5-difluoro-4-pentenoic acid esters are susceptible to a second deprotonation and, on reaction with an electrophile, give access to the a-disubstituted analogues.