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A new, short synthetic route to α-substituted 5,5-difluoro-4-pentenoic acid esters.

✍ Scribed by D.A. Kendrick; M. Kolb

Publisher: Elsevier Science
Year: 1989
Tongue: English
Weight: 340 KB
Volume: 45
Category: Article
ISSN: 0022-1139
DOI: 10.1016/s0022-1139(00)84151-2

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✦ Synopsis

The title compounds are prepared in one step from ester enolates and 3,3,3-trifluoropropene. The a-substituted 5,5-difluoro-4-pentenoic acid esters are susceptible to a second deprotonation and, on reaction with an electrophile, give access to the a-disubstituted analogues.

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